منابع مشابه
Age at Menarche and Time Spent in Education: A Mendelian Randomization Study
Menarche signifies the primary event in female puberty and is associated with changes in self-identity. It is not clear whether earlier puberty causes girls to spend less time in education. Observational studies on this topic are likely to be affected by confounding environmental factors. The Mendelian randomization (MR) approach addresses these issues by using genetic variants (such as single ...
متن کاملEarly age at menarche, lung function, and adult asthma.
RATIONALE hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes, and breast cancer. OBJECTIVES this study investigates whether age at menarche is related to adult lung function and asthma. METHODS among participants in the European Community Respiratory Health ...
متن کاملDissecting Causal Pathways Using Mendelian Randomization with Summarized Genetic Data: Application to Age at Menarche and Risk of Breast Cancer.
Mendelian randomization is the use of genetic variants as instrumental variables to estimate causal effects of risk factors on outcomes. The total causal effect of a risk factor is the change in the outcome resulting from intervening on the risk factor. This total causal effect may potentially encompass multiple mediating mechanisms. For a proposed mediator, the direct effect of the risk factor...
متن کاملMendelian Randomization Causal Analysis Adiposity as a cause of cardiovascular disease: a Mendelian randomization study
Background: Adiposity, as indicated by body mass index (BMI), has been associated with risk of cardiovascular diseases in epidemiological studies. We aimed to investigate if these associations are causal, using Mendelian randomization (MR) methods. Methods: The associations of BMI with cardiovascular outcomes [coronary heart disease (CHD), heart failure and ischaemic stroke], and associations o...
متن کاملAge at menarche: a predictor of diminished ovarian function?
OBJECTIVE To investigate whether age at menarche is associated with functional ovarian reserve (FOR) later in life. DESIGN Retrospective cohort study. SETTING Fertility center. PATIENT(S) Five hundred and two infertile women. INTERVENTION(S) None. MAIN OUTCOME MEASURE(S) Levels of menarcheal age, antimüllerian hormone (AMH), follicle-stimulating hormone (FSH), and functional ovarian r...
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ژورنال
عنوان ژورنال: European Journal of Epidemiology
سال: 2017
ISSN: 0393-2990,1573-7284
DOI: 10.1007/s10654-017-0272-9